Wellness Database: Vitamin K
Vitamin K may prevent bone loss and fracturse.
Gluten Free Diet May Improve Nutrient Levels in Children with Celiac Disease
Summary: This study examined the interrelationships between vitamin K/D status and lifestyle variables on bone mineral density (BMD) in children and adolescents with celiac disease (CD) at diagnosis and after 1 year on the gluten-free diet (GFD). Subjects (3-17 y) with CD were measured at diagnosis and after 1 year on GFD for BMD. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure. Whole-body and lumbar-spine BMD-z scores were low (+/--1) at diagnosis (10-20%) and after 1 year (30-32%) in the children, independent of symptoms. Whole-body BMD-z scores (-0.55 versus 0.72) and serum levels of 25(OH) vitamin D (90.3 versus 70.5 nmol/l) were significantly lower in older children (>10 years) when compared with younger children (+/-10 years). 43% had suboptimal vitamin D status (25(OH)-vitamin D <75 nmol/l) at diagnosis; which resolved in nearly half of the subjects after 1 year on the GFD. Twenty-five percent had suboptimal vitamin K status at diagnosis; all resolved after 1 year. Adherence to a GFD may aid in optimizing vitamin K/D intake, and thus contribute to improved BMD in children with CD.
Vitamin K May Prevent Bone Loss and Fractures
Summary: In a cross-sectional study involving 365 elderly subjects, 200 of whom were also included in a 2-year longitudinal follow-up study, dietary intake of vitamin K was found to be significantly associated with higher bone mineral density (BMD) and better quantitative ultrasound assessment (QUS), while no significant associations were found between vitamin K intake and bone biochemical markers. In addition, "Those subjects who increased their vitamin K intake showed a lower loss of BMD, a lower decrease in SOS and a nonsignificant increase in BUA." These results suggest that maintaining a higher intake of vitamin K may offer protection against bone loss and osteoporotic fractures in the elderly.
Reference: "Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women," Bullo M, Estruch R, et al, Bone, 2011 April 4; [Epub ahead of print]. (Address: Human Nutrition Unit, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain).
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